Ultrasound has helped transform our method of evaluating infertile patients.  Ultrasound technologies are the most modern addition to the gynecologist’s measures. Ultrasound can provide an image of the internal reproductive structures of the female pelvis.  Ultrasound works by submitting high frequency sound waves similar to SONAR machines in ships used for detecting submarines underwater.  The high frequency sound waves are applied to the pelvic organs and then are reflected back to the computer inside the ultrasound device. Sound waves are reflected back at different speeds to the computer, which then reconstructs the waves into black and white images on the monitor.  These revolutionary ultrasound machines are real-time machines that have real dynamic images.  The ultrasound can construct clear pictures of the uterus, the ovaries, fallopian tubes, and bladder. Gynecologists are able to look for fibroids, ectopic pregnancies, or any ovarian cysts in the pelvis. Gynecologists are able to gain knowledge that helps with even delicate procedures like tubal reversal surgery and tubal ligation reversal.

Ultrasound is also an outstanding device for early diagnosis of pregnancies. However, for some procedures, like tubal reversal, and tubal blockage (hydrosalpinx), the gynecologist may need to perform additional procedures to assess the tubes.  For tubal reversal surgery, before the procedure, it is a normal task of the infertility specialist to have an ultrasound image of the pelvic organs.

Who can perform ultrasound scans?

Ultrasound scans are performed by a radiologist, a gynecologist, or an infertility specialist. Instant decisions about your treatment, based on the images obtained, can then be made.

What is Endometrial Ablation for the management of endometriosis or ovarian cysts?

For a patient with endometriosis, and especially when ovarian cysts related to endometriosis are found (an endometrioma), managing endometriosis and ovarian cysts is effective for both reducing pain and for increasing fertility.  In patients with documented infertility, ablation of the endometriosis implants and removal of the ovarian cysts is the most effective way to restore fertility.

Conventional surgical treatment of ovarian cysts (endometriomas) involves access to the ovaries through an abdominal incision, or via laparoscopy, for drainage of the cyst contents and removal of the cyst membrane or wall.  The procedure has some disadvantages, but generally produces excellent results.  Normal ovarian tissue is unintentionally removed along with the cyst membrane or wall, which may reduce the amount of obtainable oocytes for succeeding fertility treatment.  Other complications may be experienced as a large percentage of these patients have an advanced-stage disease, or may have had multiple previous surgeries with resultant scar tissue.  In the occurrence of pelvic adhesions (scar tissue), visualization of the anatomic structures may be insufficient, and ablation of all implants may not be realized.

After endometrial ablation, patients may try to conceive through natural conception with timed intercourse (during ovulation) or by intrauterine insemination. Patients who have undergone a tubal ligation reversal may have been found to have endometriosis implants inadvertently during the tubal reversal surgery. Dr. Morice will remove any endometriomas found during the course of the tubal reversal surgery.  Since the process is linked with a small possibility of adhesion creation, some patients may form adhesions after their tubal reversal, which could lead to scarring down of the tubes and blockage of the tubes even after tubal ligation reversal. A hysterosalpingogram (HSG) is recommended 3 months after tubal ligation reversal surgery for these patients found to have endometriosis or ovarian cysts.

When is needle aspiration the best option to manage ovarian cyst(s)?

About 6% of women will have an ovarian cyst after menopause.  Factors such as age, menopausal status, size, and type of an ovarian cyst will determine the proper management of such ovarian cysts.  This information in most cases will predict whether the cysts are benign (functional), or likely to be cancerous. One option for benign cysts is needle aspiration.

Needle aspiration of ovarian cysts can sometimes be performed in the physician’s office using ultrasound guidance. The needle aspiration can be made using local anesthetic only, which is less involved than surgical operative intervention, and a patient does not require a hospital admission. Alternatively, aspiration can be done surgically, by either a laparoscopic or classical surgical approach.

There is always the risk of side effects and injury linked to the management of ovarian cysts by either medication or surgery. In the field of assisted reproductive technology (ART), and for patients having ovarian cysts after a tubal reversal, a needle aspiration is often attempted prior to a surgical intervention.  If the cysts are present during the tubal ligation reversal, they can be aspirated or removed at the time of tubal ligation reversal.

Estrogen, the primary female hormone used by a women’s body, depends primarily on ovarian follices for production.  Once there are no ovarian follicles for egg release, the level of estrogen in the body will start to fall.  Because of decreasing ovarian follicles, after a tubal reversal it is important to monitor the ovarian follicles to improve the likelihood of a pregnancy.  Estrogen also helps to control a variety of other bodily functions such as the maintenance of vaginal moisture, bone density, skin temperature, and several brain activities. The decrease of Estrogen causes most of the symptoms associated with the menopause.

Decreased Estrogen is associated with:

1. Hot flashes,
2. Vaginal dryness,
3. Mood changes,
4. Urinary incontinence,
5. Night sweats,
6. Loss of sex drive,
7. Thinning of the bones which can lead to osteoporosis

Most of these symptoms appear within 2-5 years after the initial decline of Estrogen.  The vaginal dryness is likely to worsen in older women if it is not treated.  The risk of osteoporosis also increases with age.

Estrogen as a neurotransmitter

Estrogen plays an essential role in brain activities by increasing the amount of mood-regulating neurotransmitters.  If not available, some breakdown of mood-regulating neurotransmitter triggers may result in depression.  Estrogen has been shown to increase the ability of neurons in the brain to function.  Estrogen also plays a role in the appropriate flow of blood to different parts of the brain.  As such, Estrogen plays an active role in optimizing emotion, memory, and cognitive functions. Following pregnancy, women often have a severe decrease in their Estrogen level.  As a result, 50 -70% women are estimated to have postpartum depression within the first 10 days after their delivery. 10% may suffer a major depression.  According to a study, more than 60% of women with postpartum depression may develop depression later in their lives.  During menopause and perimenopause, the striking decline in estrogen level makes women more susceptible to acute mood swings.  Many studies demonstrate to the close connection between estrogen and mood swings. Patients are often concerned about the relationship between stress and surgery, and how this will affect their Estrogen levels. Most surgeries, such as a tubal ligation reversal surgery, are short outpatient surgeries and should not affect the Estrogen level at all. Tubal reversal surgery alone will not injure the ovaries, and in general any surgery done on the fallopian tubes should not interfere with the production of Estrogen.

The hypothalamus is a small gland found at the base of the brain, which fundamentally operates as a thermostat for reproductive hormones.  It controls the levels of a number of hormones produced by providing responses to and stimulation of the pituitary gland.

How does the hypothalamus works?

The hypothalamus produces gonadotropin-releasing hormone (GnRH), which signals to increase or decrease hormone production throughout the first phase of a women’s ovulatory cycle.  In the feedback response, the pituitary increases FSH production that then causes follicle production in the ovaries. The production of estrogen is then accomplished as the follicle enlarges. As estrogen levels increase, the FSH levels eventually decrease.  Once the follicles are mature, the hypothalamus signals a spike in luteinizing hormone (LH), which leads to ovulation 36 hours later.  If something within this course is uneven or missing, and the process of ovulation does not occur, infertility will result.

Irregular ovulation can be due to numerous factors, but most frequently is secondary to the failure of the ovary to produce a follicle that ovulates.  Anovulation occurs when the ovaries cannot release eggs for fertilization. Although this is a natural consequence of aging associated with menopause, it may occur earlier in some women.

Some factors in irregular ovulation are:

1. Hyperprolactinemia – abnormally elevated prolactin levels. This may be due to a small tumor on the pituitary and may require medications and/or surgery.
2. Thyroid dysfunction – hyperthyroidism or hypothyroidism.  Thyroid levels can cause irregular ovulation. Medications can be used to treat thyroid dysfunction.
3. Adrenal disorders.  Androgens are male hormones, such as testosterone, produced by the ovaries and adrenal gland.  High levels may lead to oligo-ovulation.
4. Environmental factors like pollution, radiation, etc.
5. Excessive exercise, obesity, and/or stress

Fertility treatments are available for such cases.  In these situations, it is assumed that the fallopian tubes are still open, unless the patient has had a tubal ligation surgery. A special test called a hysterosalpingogram can be done to make sure that the fallopian tubes are open. If the patient has had a tubal ligation, she would need to have a tubal reversal performed to open the tubes again. Any patient who will be undergoing a tubal ligation reversal would benefit from a hormonal evaluation prior to the tubal reversal surgery to ensure that once her tubes were reversed, she would not have infertility from a hormonal issue.

What is HCG?

HCG stands for human chorionic gonadotropin, and is known as ‘the pregnancy hormone.’  HCG is formed by trophoblastic cells in the embryo (pregnancy).  These cells occupy the uterine lining and build up into the placenta.

What essential work is done by HCG in the pregnancy?

HCG stimulates the ovary to make progesterone.  Progesterone is the hormone that maintains the endometrial lining of the uterus for carrying the pregnancy.  In the normal menstrual cycle, progesterone made by the ovary only lasts for 2-weeks after ovulation.  After 2-weeks, the progesterone level falls and menstruation begins.  However, if pregnancy occurs, HCG stimulates the ovaries to produce progesterone to prevent menstrual bleeding.

Early pregnancy monitoring after tubal ligation reversal through HCG

Pregnancy tests perceive HCG.  Urine pregnancy tests typically can identify HCG within 14-16 days after ovulation.  Blood pregnancy tests are more receptive for a positive pregnancy and can perceive HCG within 10-12 days after ovulation.

Quantitative tests for HCG

Whether urine or blood tests, are those that actually measure the HCG in the blood stream.  When women become pregnant after tubal ligation reversal surgery, quantitative HCG assays should be performed as soon as a positive home pregnancy test (a qualitative test) is positive.  Once the quantitative serum HCG levels reaches 1500-2000 mIU/ml, a vaginal ultrasound should be able to identify a gestation sac within the uterus.

HCG doubling time

In a normally developing pregnancy, quantitative serum HCG levels increase twofold every 2-3 days during the initial weeks of pregnancy. Repeating HCG tests after a tubal reversal surgery can help indentify normal pregnancies versus ectopic or abnormal pregnancies.